While Kawasaki disease is rare, it is considered to be the commonest cause of acquired heart disease in childhood, killing around 1 per cent of the children affected.
Epidemiological research has shown that Kawasaki disease affects between eight and 33 per 100,000 children under the age of five in the Western world; the incidence is much higher in Japan. However, it is on the increase. Children between six months and five years old are most at risk, particularly those of north-east Asian origin. It occurs more commonly in the spring and winter in temperate regions.
Essentially, Kawasaki disease is a type of vasculitis, which describes an inflammatory condition of the blood vessels. It is thought to be caused by an infectious agent, although the exact cause has yet to be proven. There is evidence that genetics play a role in a person's susceptibility to acquiring Kawasaki disease.
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